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| T4-HRP conjugate |
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Product Data |
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| Request info |
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| | Product Name | T4-HRP conjugate |
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| | Synonyms | thyroxine T4 - horseradish peroxidase conjugate |
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| | Catalog No | T4HRP.2 |
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| | Size | 5 mg |
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| | Price | 1.545,00 EUR |
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| | Category | drug HRP-conjugates |
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| | Description | T4, covalently linked to horseradish peroxidase |
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| | Feature | L-Thyroxine - enzyme conjugate with horseradish peroxidase; Reagent for T4 (L-Thyroxine) ELISA with commonly used anti T4-antibodies; High activity; Improved stability |
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| | Molecular Weight | app. 44 kDa |
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| | Presentation | lyophilized, 5 mg, essentially salt free |
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| | Reconstitution | reconstitute with 5 ml PBS without azide |
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| | Stabilizer | none |
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| | Storage | -20°C |
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| | Conjugate/Tag/Label | T4 (L-Thyroxine) |
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| | Conjugation Ratio | 1:1 |
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| | Protein Source | horseradish peroxidase type VI-A |
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| | Applications | T4 immunoassays development or other applications. |
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| | Use | For research use only. Not intended for diagnostic use. |
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| | Purification | preparative SEC chromatography |
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| | Concentration | 1 mg/ml working concentration |
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| | Purity | >99% (HPLC) |
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| | Activity | 1500U/mg solid |
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| | Working Dilution | working dilution: 1:5000 - 1:10000 |
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| | Source | horseradish |
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| | Additional Info | The thyroid hormones, triiodothyronine (T3) and thyroxine (T4), are tyrosine-based hormones produced by the thyroid gland that are primarily responsible for regulation of metabolism. Iodine is necessary for the production of T3 and T4. A deficiency of iodine leads to decreased production of T3 and T4, enlarges the thyroid tissue and will cause the disease known as goitre. The major form of thyroid hormone in the blood is thyroxine (T4), which has a longer half-life than T3. The ratio of T4 to T3 released into the blood is roughly 20 to 1. T4 is converted to the active T3 (three to four times more potent than T4) within cells by deiodinases (5'-iodinase). These are further processed by decarboxylation and deiodination to produce iodothyronamine (T1a) and thyronamine (T0a). All three isoforms of the deiodinases are selenium-containing enzymes, thus dietary selenium is essential for T3 production. |
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| | Remarks | conjugate with improved stability |
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