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Product Data |
| | mAb to O6-methyl-2-deoxyguanosine (EM 2-3) |
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Product Name |
mAb to O6-methyl-2-deoxyguanosine (EM 2-3) |
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Synonyms |
EM 2-3 monoclonal antibody |
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Catalog No |
SQM003.1 |
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Size |
100 µg |
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Price |
425,00 EUR |
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Category |
Antibodies and Conjugates |
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Description |
monoclonal antibody, specific for O6-methyl-2-deoxyguanosine |
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Background |
DNA-lesion specific monoclonal antibody |
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Feature |
Detects a specific mutagenic DNA modification induced by several exogenous and endogenous carcinogens e.g. food, smoking, cancer therapeutics, environmental carcinogens, workplace carcinogens; Molecular epidemiology of carcinogen exposure; Pre- and intratherapeutic dosimetry of exposure to anticancer agents; Basic research of molecular mechanisms of carcinogenesis; Mutagenicity testing of substances |
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Appearance |
160 kDa |
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Reconstitution |
lyophilized |
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Stabilizer |
reconstitute with 1 ml of PBS, 0.05% sodium azide, 1% bovine serum albumine |
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Storage |
none |
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Conjugate/Tag/Label |
-20°C |
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Use |
competitive radioimmunoassay; ELISA; Immunoaffinity/Quantitative PCR; Immunocytochemistry: 0.05 - 0.2 µg/ml PBS containing 3% bovine serum albumin |
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Host |
specifically reacts with O6-methyl-2-deoxyguanosine in human, mouse, rat, hamster |
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Isotype |
mouse |
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Clonality |
IgG1 |
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Clone |
monoclonal |
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Immunogen |
EM 2-3 |
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Specificity |
O6-methyl-2-deoxyguanosine-Thyroglubulin conjugate |
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Cross Reactions |
O6-methyl/ethyl/butyl-2-deoxyguanosine |
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Affinity Constant |
in immunocytochemistry the antibody crossreacts efficiently with O6-ethyl-2-deoxyguanosine and O6-butyl-2-deosyguanosine |
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Purification |
4.4 x 10 e8 (l/Mol) |
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Concentration |
Protein G affinity purification from cell culture supernatant |
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Activity |
>95% |
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Source |
test dependent |
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Considerations for Use |
1 year |
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Additional Info |
Please store the vial at 4-8 deg. C. The product is stable for 1 year at 4-8 deg. C in its stock solution. Working dilutions should always be prepared freshly. For extended storage of the stock solution please add 50% glycerol and freeze the product. |
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| Squarix GmbH - Elbestraße 10 - D-45768 Marl - Germany |
| fon: +49-2365-20400-0 - fax: +49-2365-20400-60 - www.squarix.de - e-mail: info@squarix.de |