Volume 3
 
New building blocks for metathesis
 
The Squarix Newsletter provides you with information about our innovative building blocks, reactive intermediates and screening compounds from our Discovery Chemicals portfolio.
 
In this issue we present new N-protected Olefin building blocks, especially designed for Ring-Closing Metathesis (RCM) applications. These compounds are derived from natural and unnatural amino acides and not commercially available from other manufacturers. Please find below a sample list of these new building blocks.

See our website for the full line of building blocks or download the Discovery Chemicals catalogue.
 
Featured Products
VA005 VA006 VA007
VA005 VA006 VA007
 
VA010 VA030 VA040
VA010 VA030 VA040
 
VA034 VA041
VA034 VA041
 
See below examples of possible useful transformations using our building blocks to synthesize e.g. macrocylic ring systems or nitrogen containing heterocycles via ring-closing metathesis (RCM):
 
reactions
VA025 AS050      
 
reactions
VA008        
 
Please find also some selected references from the literature describing interesting applications of Ring-Closing Metathesis reactions. The solid phase syntheses of cyclic peptoids (Khan et al.), the syntheses of nitrogen heterocycles (Kuhn et al.) and the synthesis of bicyclic lactams (Barret et al.):
 
Please find also some selected references from the literature describing interesting applications of Ring-Closing Metathesis reactions. The solid phase syntheses of cyclic peptoids (Khan et al.), the syntheses of nitrogen heterocycles (Kuhn et al.) and the synthesis of bicyclic lactams (Barret et al.):
 
reactions
 
References
 
1) S.N. Khan, A. Kim, R.H. Grubbs and Y-U. Kwon. Ring-Closing Metathesis Approaches for the Solid-Phase Synthesis of Cyclic Peptoids, Org. Lett. 2011, 13, 1582-1585.
2) K.M. Kuhn, T. M. Champagne, S.H. Hong, W-H. Wei, A. Nickel, C.W. Lee, S. C. Virgil, R. H. Grubbs and R.L. Pederson., Low Catalyst Loadings in Olefin Metathesis: Synthesis of Nitrogen Heterocycles by Ring-Closing Metathesis, Org. Lett. 2010, 12, 984-987.
3) A.G.M. Barret, SPD. Baugh, V.C. Gibson, M.R. Giles, E.L. Marshall and P.A. Procopiou. Highly Functionalized Monocyclic and Bicyclic -Lactams via Alkene Metathesis, Chem. Commun. 1997, 155.
   
Discovery Chemicals
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catalogue
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  [PDF]
 

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