Volume 6   New Heterocyclic Amino Acid Building Blocks   The Squarix Newsletter provides you with information about our innovative building blocks, reactive intermediates and screening compounds from our Discovery Chemicals portfolio.   In this issue we present new heterocyclic amino acid building blocks especially designed for stereocontrolled synthesis of peptidomimetics and new platforms for supramolecular chemistry.   Featured Products       PM002   PM102   PM095         PM101   PM142   PM096         PM139   PM138   PM106   These compounds are derived from natural amino acids and are not commercially available from other manufacturers.   See our website for the full line of building blocks or download the Discovery Chemicals catalogue.   Please find also some selected references from the literature describing interesting applications of our new building blocks. (-)-Muscoride A, a bioxazole peptide alkaloid was synthetized by Wipf and Venkatraman using the key building block PM030. Haberhauer et al. reported an efficient syntheses of C2-symmetric macrocyclic receptors using the imidazol building block PM139 as starting material.         PM030   (-)-Muscoride A (Wipf and Venkatraman)         PM139   C2 -symmetric macrocyclic receptor (Haberhauer et al.)   References   1) P. Wipf, and S. Venkatraman, Total Synthesis of (-)-Muscoride A 1996, J. Org. Chem. 61, 6517-6522. 2) A. Pinter, G. Haberhauer, Thieme Chemistry Journal Awardees - Where Are They Now ? - Macrocyclic Peptide Chemistry Inspired by Nature - From Chiral Artificial Receptors toward Molecular Devices. Synlett 2009, 3082-3098. 3) M. Schnopp, S. Ernst, and G. Haberhauer, Anion Recognition by Neutral Macrocyclic Azole Amides 2009, J. Org. Chem. 63, 2469-2474. 4) L. Somogyi, G. Haberhauer and J.Rebek, Jr., Improved synthesis of functionalized molecular platforms related to marine cyclopeptides. 2001, Tetrahedron 57, 1699-1708.			Discovery Chemicals Custom Synthesis   Call us for a quote: +49-2365-20400-0   Squarix GmbH Elbestrasse 10 D-45768 Marl Germany   fon: +49-2365-20400-0 fax: +49-2365-20400-60 web: www.squarix.de e-mail: info@squarix.de   subscribe to Squarix newsletter unsubscribe from Squarix newsletter   Download catalogue   [PDF]
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