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T4-HRP | |
Cat. No. T4HRP.1 (1 mg)
Cat. No. T4HRP.2 (5 mg)
Cat. No. T4HRP.3 (10 mg) |
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| T4 - Horseradish Peroxidase Conjugate |
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L-Thyroxine - enzyme conjugate with horseradish peroxidase |
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Reagent for T4 ELISA with commonly used anti T4-antibodies |
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High activity |
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Improved stability |
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Product Data |
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Product name |
T4-HRP |
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raw material |
horseradish peroxidase type VI-A |
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activity |
1500 U/mg solid |
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label |
T4 (L-Thyroxine) |
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quantity |
1 mg / 5 mg / 10 mg |
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conjugation ratio |
POD/T4: 1:1 |
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purity |
> 99% (HPLC) |
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form |
lyophilised, essentially salt free |
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reconstitution |
1 ml PBS without azide (T4HRP.1)
5 ml PBS without azide (T4HRP.2)
10 ml PBS without azide (T4HRP.3) |
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working dilution (ELISA) |
1:5000 - 1:10000 |
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storage |
-20°C, dry |
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usage |
For research use only. Not intended for diagnostic use. Suitable for use in immunoassay development or other applications. |
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keywords |
thyroxine; T4; T3; thx; thyroxinal; Thyrax; Henning; tetraiodothyronine, triiodothyronine, diiodophenyl-L-alanine; DL-thyroxine; T4-HRP, T4-POD |
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Information |
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The thyroid hormones, triiodothyronine (T3) and thyroxine (T4), are tyrosine-based hormones produced by the thyroid gland that are primarily responsible for regulation of metabolism. Iodine is necessary for the production of T3 and T4. A deficiency of iodine leads to decreased production of T3 and T4, enlarges the thyroid tissue and will cause the disease known as goitre. The major form of thyroid hormone in the blood is thyroxine (T4), which has a longer half-life than T3. The ratio of T4 to T3 released into the blood is roughly 20 to 1. T4 is converted to the active T3 (three to four times more potent than T4) within cells by deiodinases (5'-iodinase). These are further processed by decarboxylation and deiodination to produce iodothyronamine (T1a) and thyronamine (T0a). All three isoforms of the deiodinases are selenium-containing enzymes, thus dietary selenium is essential for T3 production. |
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References |
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1) Kirkegaard C, Faber J (1998). "The role of thyroid hormones in depression". Eur J Endocrinol 138 (1): 1-9. |
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2) Dratman M, Gordon J (1996). "Thyroid hormones as neurotransmitters". Thyroid 6 (6): 639-47. |
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| | Ordering Information |
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Cat. No. |
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Product Name |
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Quantity |
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Price* |
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T4HRP.1 |
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thyroxine T4 - horseradish peroxidase conjugate |
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1 mg |
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395,00 EUR |
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T4HRP.2 |
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thyroxine T4 - horseradish peroxidase conjugate |
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5 mg |
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1.545,00 EUR |
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T4HRP.3 |
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thyroxine T4 - horseradish peroxidase conjugate |
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10 mg |
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2.295,00 EUR |
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* For bulk package size please inquire. Prices do not contain shipping costs, please inquire. Last updated: June 06 2023 |
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